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Showing 1 to 60 of 60 entries
pdb_idclassmethodauthorsreferenceabstractannotation
3C2I transcription regulator X-ray (2.5 Å) Ho, K.L., McNae, I.W., Schmiedeberg, L., Klose, R.J., Bird, A.P., Walkinshaw, M.D. (2008) "MeCP2 binding to DNA depends upon hydration at methyl-CpG." Mol.Cell, 29, 525-531. MeCP2 is an essential transcriptional repressor that mediates gene silencing through binding to methylated DNA. Binding specificity has been thought to depend onread more The crystal structure of methyl-cpg binding domain of human mecp2 in complex with a methylated DNA sequence from bdnf. 2 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:AcG/cGT, [-]:cGG/CcG
3SSC DNA binding protein-DNA X-ray (2.1 Å) Sukackaite, R., Grazulis, S., Tamulaitis, G., Siksnys, V. (2012) "The recognition domain of the methyl-specific endonuclease McrBC flips out 5-methylcytosine." Nucleic Acids Res., 40, 7552-7562. DNA cytosine methylation is a widespread epigenetic mark. Biological effects of DNA methylation are mediated by the proteins that preferentially bind to 5-read more DNA binding domain of restriction endonuclease bound to DNA. 2 5mC groups: stacking-with-AA, not-WC-paired, not-in-duplex
3SSD DNA binding protein-DNA X-ray (2.2 Å) Sukackaite, R., Grazulis, S., Tamulaitis, G., Siksnys, V. (2012) "The recognition domain of the methyl-specific endonuclease McrBC flips out 5-methylcytosine." Nucleic Acids Res., 40, 7552-7562. DNA cytosine methylation is a widespread epigenetic mark. Biological effects of DNA methylation are mediated by the proteins that preferentially bind to 5-read more DNA binding domain of restriction endonuclease bound to DNA. 1 5mC group: stacking-with-AA, not-WC-paired, not-in-duplex
4F6N DNA binding protein-DNA X-ray (2.8 Å) Buck-Koehntop, B.A., Stanfield, R.L., Ekiert, D.C., Martinez-Yamout, M.A., Dyson, H.J., Wilson, I.A., Wright, P.E. (2012) "Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein Kaiso." Proc.Natl.Acad.Sci.USA, 109, 15229-15234. Methylation of CpG dinucleotides in DNA is a common epigenetic modification in eukaryotes that plays a central role in maintenance of genome stability, gene silencing,read more Crystal structure of kaiso zinc finger DNA binding protein in complex with methylated cpg site DNA. 4 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:CcG/cGG, other-contacts, [+]:GcG/cGc, [-]:cGT/AcG, [-]:cGc/GcG
4GJP transcription-DNA X-ray (1.94 Å) Yan, N., Deng, D., Yan, C.Y., Yin, P., Pan, X.J., Shi, Y.G. "Crystal structure of a protein complex." To be Published   Crystal structure of the tal effector dhax3 bound to dsDNA containing repetitive methyl-cpg. 4 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:TcG/CGA, [+]:GcG/CGC
4GJR transcription-DNA X-ray (1.85 Å) Yan, N., Deng, D., Yan, C.Y., Yin, P., Pan, X.J., Shi, Y.G. "Crystal structure of a protein complex." To be Published   Crystal structure of the tal effector dhax3 bound to methylated dsDNA. 6 5mC groups: hydrophobic-with-AA, is-WC-paired, is-in-duplex, [+]:TcT/AGA, stacking-with-AA, [+]:AcC/GGT, [+]:CcC/GGG
4GZN transcription-DNA X-ray (0.99 Å) Liu, Y., Toh, H., Sasaki, H., Zhang, X., Cheng, X. (2012) "An atomic model of Zfp57 recognition of CpG methylation within a specific DNA sequence." Genes Dev., 26, 2374-2379. Zinc finger transcription factor Zfp57 recognizes the methylated CpG within the TGCCGC element. We determined the structure of the DNA-binding domain of Zfp57,read more Mouse zfp57 zinc fingers in complex with methylated DNA. 2 5mC groups: other-contacts, is-WC-paired, is-in-duplex, [+]:CcG/cGG, stacking-with-AA, [-]:cGC/GcG
4HP1 DNA binding protein-DNA X-ray (2.25 Å) Xu, Y., Xu, C., Kato, A., Tempel, W., Abreu, J.G., Bian, C., Hu, Y., Hu, D., Zhao, B., Cerovina, T., Diao, J., Wu, F., He, H.H., Cui, Q., Clark, E., Ma, C., Barbara, A., Veenstra, G.J., Xu, G., Kaiser, U.B., Liu, X.S., Sugrue, S.P., He, X., Min, J., Kato, Y., Shi, Y.G. (2012) "Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development." Cell, 151, 1200-1213. Ten-Eleven Translocation (Tet) family of dioxygenases dynamically regulates DNA methylation and has been implicated in cell lineage differentiation and oncogenesis.read more Crystal structure of tet3 in complex with a non-cpg dsDNA. 2 5mC groups: other-contacts, is-WC-paired, is-in-duplex, [+]:CcG/cGG, [-]:cGG/CcG
4M9E transcription-DNA X-ray (1.85 Å) Liu, Y., Olanrewaju, Y.O., Zheng, Y., Hashimoto, H., Blumenthal, R.M., Zhang, X., Cheng, X. (2014) "Structural basis for Klf4 recognition of methylated DNA." Nucleic Acids Res., 42, 4859-4867. Transcription factor Krüppel-like factor 4 (Klf4), one of the factors directing cellular reprogramming, recognizes the CpG dinucleotide (whether methylated orread more Structure of klf4 zinc finger DNA binding domain in complex with methylated DNA. 2 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:GcG/cGC, other-contacts, [-]:cGT/AcG
4M9V transcription-DNA X-ray (0.97 Å) Liu, Y., Olanrewaju, Y.O., Zhang, X., Cheng, X. (2013) "DNA recognition of 5-carboxylcytosine by a zfp57 mutant at an atomic resolution of 0.97 angstrom." Biochemistry, 52, 9310-9317. The Zfp57 gene encodes a KRAB (Krüppel-associated box) domain-containing C2H2 zinc finger transcription factor that is expressed in early development. Zfp57 proteinread more Zfp57 mutant (e182q) in complex with 5-carboxylcytosine DNA. 2 5mC groups: other-contacts, is-WC-paired, is-in-duplex, [+]:CcG/cGG
4QEN transcription-DNA X-ray (2.0 Å) Du, J., Johnson, L.M., Groth, M., Feng, S., Hale, C.J., Li, S., Vashisht, A.A., Gallego-Bartolome, J., Wohlschlegel, J.A., Patel, D.J., Jacobsen, S.E. (2014) "Mechanism of DNA Methylation-Directed Histone Methylation by KRYPTONITE." Mol.Cell, 55, 495-504. In Arabidopsis, CHG DNA methylation is controlled by the H3K9 methylation mark through a self-reinforcing loop between DNA methyltransferase CHROMOMETHYLASE3 (CMT3)read more Crystal structure of kryptonite in complex with mchh DNA and sah. 1 5mC group: stacking-with-AA, not-WC-paired, not-in-duplex
4QEO transcription-DNA X-ray (2.0 Å) Du, J., Johnson, L.M., Groth, M., Feng, S., Hale, C.J., Li, S., Vashisht, A.A., Gallego-Bartolome, J., Wohlschlegel, J.A., Patel, D.J., Jacobsen, S.E. (2014) "Mechanism of DNA Methylation-Directed Histone Methylation by KRYPTONITE." Mol.Cell, 55, 495-504. In Arabidopsis, CHG DNA methylation is controlled by the H3K9 methylation mark through a self-reinforcing loop between DNA methyltransferase CHROMOMETHYLASE3 (CMT3)read more Crystal structure of kryptonite in complex with mchh DNA, h3(1-15) peptide and sah. 1 5mC group: stacking-with-AA, not-WC-paired, not-in-duplex
4R2A DNA binding protein-DNA X-ray (1.59 Å) Hashimoto, H., Olanrewaju, Y.O., Zheng, Y., Wilson, G.G., Zhang, X., Cheng, X. (2014) "Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence." Genes Dev., 28, 2304-2313. In mammalian DNA, cytosine occurs in several chemical forms, including unmodified cytosine (C), 5-methylcytosine (5 mC), 5-hydroxymethylcytosine (5 hmC), 5-read more Egr1-zif268 zinc fingers in complex with methylated DNA. 2 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:GcG/cGC, other-contacts, [-]:cGT/AcG
4R2E DNA binding protein-DNA X-ray (1.84 Å) Hashimoto, H., Olanrewaju, Y.O., Zheng, Y., Wilson, G.G., Zhang, X., Cheng, X. (2014) "Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence." Genes Dev., 28, 2304-2313. In mammalian DNA, cytosine occurs in several chemical forms, including unmodified cytosine (C), 5-methylcytosine (5 mC), 5-hydroxymethylcytosine (5 hmC), 5-read more Wilms tumor protein (wt1) zinc fingers in complex with methylated DNA. 2 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:GcG/cGC, other-contacts, [-]:cGT/AcG
4R2R DNA binding protein-DNA X-ray (2.09 Å) Hashimoto, H., Olanrewaju, Y.O., Zheng, Y., Wilson, G.G., Zhang, X., Cheng, X. (2014) "Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence." Genes Dev., 28, 2304-2313. In mammalian DNA, cytosine occurs in several chemical forms, including unmodified cytosine (C), 5-methylcytosine (5 mC), 5-hydroxymethylcytosine (5 hmC), 5-read more Wilms tumor protein (wt1) zinc fingers in complex with carboxylated DNA. 1 5mC group: other-contacts, is-WC-paired, is-in-duplex, [-]:cGT/AcG
4R2S DNA binding protein-DNA X-ray (2.49 Å) Hashimoto, H., Olanrewaju, Y.O., Zheng, Y., Wilson, G.G., Zhang, X., Cheng, X. (2014) "Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence." Genes Dev., 28, 2304-2313. In mammalian DNA, cytosine occurs in several chemical forms, including unmodified cytosine (C), 5-methylcytosine (5 mC), 5-hydroxymethylcytosine (5 hmC), 5-read more Wilms tumor protein (wt1) q369p zinc fingers in complex with methylated DNA. 2 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:GcG/cGC, other-contacts, [-]:cGT/AcG
4X9J transcription regulator-DNA X-ray (1.41 Å) Zandarashvili, L., White, M.A., Esadze, A., Iwahara, J. (2015) "Structural impact of complete CpG methylation within target DNA on specific complex formation of the inducible transcription factor Egr-1." Febs Lett., 589, 1748-1753. The inducible transcription factor Egr-1 binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases.read more Egr-1 with doubly methylated DNA. 4 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:GcG/cGC, other-contacts, [-]:cGT/AcG
5BT2 DNA binding protein-DNA X-ray (2.2 Å) Chia, J.Y., Tan, W.S., Ng, C.L., Hu, N.J., Foo, H.L., Ho, K.L. (2016) "A/T Run Geometry of B-form DNA Is Independent of Bound Methyl-CpG Binding Domain, Cytosine Methylation and Flanking Sequence." Sci Rep, 6, 31210-31210.   Mecp2 mbd domain (a140v) in complex with methylated DNA. 2 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:AcG/cGT, [-]:cGG/CcG
5CPK structural protein-DNA X-ray (2.63 Å) Osakabe, A., Adachi, F., Arimura, Y., Maehara, K., Ohkawa, Y., Kurumizaka, H. (2015) "Influence of DNA methylation on positioning and DNA flexibility of nucleosomes with pericentric satellite DNA." Open Biology, 5 DNA methylation occurs on CpG sites and is important to form pericentric heterochromatin domains. The satellite 2 sequence, containing seven CpG sites, is located inread more Nucleosome containing methylated sat2l DNA. 1 5mC group: other-contacts, is-WC-paired, is-in-duplex, [+]:TcG/cGA
5EF6 transcription X-ray (3.0 Å) Yin, Y., Morgunova, E., Jolma, A., Kaasinen, E., Sahu, B., Khund-Sayeed, S., Das, P.K., Kivioja, T., Dave, K., Zhong, F., Nitta, K.R., Taipale, M., Popov, A., Ginno, P.A., Domcke, S., Yan, J., Schubeler, D., Vinson, C., Taipale, J. (2017) "Impact of cytosine methylation on DNA binding specificities of human transcription factors." Science, 356 The majority of CpG dinucleotides in the human genome are methylated at cytosine bases. However, active gene regulatory elements are generally hypomethylated relativeread more Structure of hoxb13 complex with methylated DNA. 8 5mC groups: hydrophobic-with-AA, is-WC-paired, is-in-duplex, [+]:AcG/cGT, [-]:cGA/TcG, [-]:cGG/CcG
5EGO transcription X-ray (2.54 Å) Yin, Y., Morgunova, E., Jolma, A., Kaasinen, E., Sahu, B., Khund-Sayeed, S., Das, P.K., Kivioja, T., Dave, K., Zhong, F., Nitta, K.R., Taipale, M., Popov, A., Ginno, P.A., Domcke, S., Yan, J., Schubeler, D., Vinson, C., Taipale, J. (2017) "Impact of cytosine methylation on DNA binding specificities of human transcription factors." Science, 356 The majority of CpG dinucleotides in the human genome are methylated at cytosine bases. However, active gene regulatory elements are generally hypomethylated relativeread more Hoxb13-meis1 heterodimer bound to methylated DNA. 2 5mC groups: hydrophobic-with-AA, is-WC-paired, is-in-duplex, [+]:AcG/cGT, [-]:cGA/TcG
5EMC transcription-DNA X-ray (2.3 Å) Jin, J., Lian, T., SU, X.D. "The effects of cytosine methylation on general transcription factors." To Be Published   Transcription factor grdbd and smgre complex. 1 5mC group: other-contacts, is-WC-paired, is-in-duplex, [-]:TGT/AcA
5KE7 transcription-DNA X-ray (2.06 Å) Hashimoto, H., Wang, D., Steves, A.N., Jin, P., Blumenthal, R.M., Zhang, X., Cheng, X. (2016) "Distinctive Klf4 mutants determine preference for DNA methylation status." Nucleic Acids Res., 44, 10177-10185. Reprogramming of mammalian genome methylation is critically important but poorly understood. Klf4, a transcription factor directing reprogramming, contains a DNAread more Mouse klf4 znf1-3 and tpg-mpa sequence DNA complex structure. 1 5mC group: other-contacts, is-WC-paired, is-in-duplex, [-]:TGT/AcA
5KE8 transcription-DNA X-ray (2.45 Å) Hashimoto, H., Wang, D., Steves, A.N., Jin, P., Blumenthal, R.M., Zhang, X., Cheng, X. (2016) "Distinctive Klf4 mutants determine preference for DNA methylation status." Nucleic Acids Res., 44, 10177-10185. Reprogramming of mammalian genome methylation is critically important but poorly understood. Klf4, a transcription factor directing reprogramming, contains a DNAread more Mouse klf4 e446p znf1-3 and mpg-mpg sequence DNA complex structure. 2 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:GcG/cGC, other-contacts, [-]:cGT/AcG
5KL4 transcription-DNA X-ray (1.78 Å) Hashimoto, H., Zhang, X., Zheng, Y., Wilson, G.G., Cheng, X. (2016) "Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modifications." Nucleic Acids Res., 44, 10165-10176. Mutations in human zinc-finger transcription factor WT1 result in abnormal development of the kidneys and genitalia and an array of pediatric problems includingread more Wilms tumor protein (wt1) znf2-4 q369h in complex with formylated DNA. 2 5mC groups: other-contacts, is-WC-paired, is-in-duplex, [-]:cGT/AcG
5KL5 transcription-DNA X-ray (2.29 Å) Hashimoto, H., Zhang, X., Zheng, Y., Wilson, G.G., Cheng, X. (2016) "Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modifications." Nucleic Acids Res., 44, 10165-10176. Mutations in human zinc-finger transcription factor WT1 result in abnormal development of the kidneys and genitalia and an array of pediatric problems includingread more Wilms tumor protein (wt1) znf2-4 q369h in complex with carboxylated DNA. 1 5mC group: other-contacts, is-WC-paired, is-in-duplex, [-]:cGT/AcG
5KL7 transcription-DNA X-ray (1.58 Å) Hashimoto, H., Zhang, X., Zheng, Y., Wilson, G.G., Cheng, X. (2016) "Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modifications." Nucleic Acids Res., 44, 10165-10176. Mutations in human zinc-finger transcription factor WT1 result in abnormal development of the kidneys and genitalia and an array of pediatric problems includingread more Wilms tumor protein (wt1) znf2-4q369r in complex with carboxylated DNA. 1 5mC group: other-contacts, is-WC-paired, is-in-duplex, [-]:cGT/AcG
5LTY transcription X-ray (2.66 Å) Yin, Y., Morgunova, E., Jolma, A., Kaasinen, E., Sahu, B., Khund-Sayeed, S., Das, P.K., Kivioja, T., Dave, K., Zhong, F., Nitta, K.R., Taipale, M., Popov, A., Ginno, P.A., Domcke, S., Yan, J., Schubeler, D., Vinson, C., Taipale, J. (2017) "Impact of cytosine methylation on DNA binding specificities of human transcription factors." Science, 356 The majority of CpG dinucleotides in the human genome are methylated at cytosine bases. However, active gene regulatory elements are generally hypomethylated relativeread more Homeobox transcription factor cdx2 bound to methylated DNA. 2 5mC groups: hydrophobic-with-AA, is-WC-paired, is-in-duplex, [+]:AcG/cGT
5MCV transcription X-ray (1.6 Å) Golovenko, D., Brauning, B., Vyas, P., Haran, T.E., Rozenberg, H., Shakked, Z. (2018) "New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins." Structure, 26, 1237-1250.e6. The tumor suppressor p53 acts as a transcription factor recognizing diverse DNA response elements (REs). Previous structural studies of p53-DNA complexes revealed non-read more New insights into the role of DNA shape on its recognition by p53 proteins (complex p53dbd-lwc1). 4 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:gcG/Cgc, [-]:Cgc/gcG
5MCW transcription X-ray (1.9 Å) Golovenko, D., Brauning, B., Vyas, P., Haran, T.E., Rozenberg, H., Shakked, Z. (2018) "New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins." Structure, 26, 1237-1250.e6. The tumor suppressor p53 acts as a transcription factor recognizing diverse DNA response elements (REs). Previous structural studies of p53-DNA complexes revealed non-read more New insights into the role of DNA shape on its recognition by p53 proteins (complex p53dbd-lwc2). 4 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:gcG/Cgc, [-]:Cgc/gcG
5SZX transcription regulator-DNA X-ray (2.25 Å) Hong, S., Wang, D., Horton, J.R., Zhang, X., Speck, S.H., Blumenthal, R.M., Cheng, X. (2017) "Methyl-dependent and spatial-specific DNA recognition by the orthologous transcription factors human AP-1 and Epstein-Barr virus Zta." Nucleic Acids Res., 45, 2503-2515. Activator protein 1 (AP-1) is a transcription factor that recognizes two versions of a 7-base pair response element, either 5΄- GAG CA-3΄ or 5΄- GAG CA-3΄ (where M = 5-read more Epstein-barr virus zta DNA binding domain homodimer in complex with methylated DNA. 2 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:TcG/cGA, other-contacts, [-]:cGC/GcG
5T00 transcription regulator-DNA X-ray (2.19 Å) Hashimoto, H., Wang, D., Horton, J.R., Zhang, X., Corces, V.G., Cheng, X. (2017) "Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA." Mol. Cell, 66, 711-720.e3. The multidomain CCCTC-binding factor (CTCF), containing a tandem array of 11 zinc fingers (ZFs), modulates the three-dimensional organization of chromatin. Weread more Human ctcf znf3-7 and methylated DNA complex. 4 5mC groups: other-contacts, is-WC-paired, is-in-duplex, [+]:GcG/cGC, stacking-with-AA, [-]:cGC/GcG
5T01 transcription regulator-DNA X-ray (1.89 Å) Hong, S., Wang, D., Horton, J.R., Zhang, X., Speck, S.H., Blumenthal, R.M., Cheng, X. (2017) "Methyl-dependent and spatial-specific DNA recognition by the orthologous transcription factors human AP-1 and Epstein-Barr virus Zta." Nucleic Acids Res., 45, 2503-2515. Activator protein 1 (AP-1) is a transcription factor that recognizes two versions of a 7-base pair response element, either 5΄- GAG CA-3΄ or 5΄- GAG CA-3΄ (where M = 5-read more Human c-jun DNA binding domain homodimer in complex with methylated DNA. 1 5mC group: hydrophobic-with-AA, is-WC-paired, is-in-duplex, [-]:CGT/AcG
5VMU transcription-DNA X-ray (2.35 Å) Nikolova, E.N., Stanfield, R.L., Dyson, H.J., Wright, P.E. (2018) "CH···O Hydrogen Bonds Mediate Highly Specific Recognition of Methylated CpG Sites by the Zinc Finger Protein Kaiso." Biochemistry, 57, 2109-2120. Many eukaryotic transcription factors recognize the epigenetic marker 5-methylcytosine (mC) at CpG sites in DNA. Despite their structural diversity, methyl-CpG-bindingread more Kaiso (zbtb33) zinc finger DNA binding domain in complex with a double cpg-methylated DNA resembling the specific kaiso binding sequence (kbs). 4 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:CcG/cGG, other-contacts, [+]:GcG/cGc, [-]:cGA/TcG, [-]:cGc/GcG
5VMV transcription-DNA X-ray (2.31 Å) Nikolova, E.N., Stanfield, R.L., Dyson, H.J., Wright, P.E. (2018) "CH···O Hydrogen Bonds Mediate Highly Specific Recognition of Methylated CpG Sites by the Zinc Finger Protein Kaiso." Biochemistry, 57, 2109-2120. Many eukaryotic transcription factors recognize the epigenetic marker 5-methylcytosine (mC) at CpG sites in DNA. Despite their structural diversity, methyl-CpG-bindingread more Kaiso (zbtb33) zinc finger DNA binding domain in complex with its double cpg-methylated DNA consensus binding site. 4 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:TcG/cGA, other-contacts, [+]:GcG/cGc, [-]:cGA/TcG, [-]:cGc/GcG
5VMW transcription-DNA X-ray (2.4 Å) Nikolova, E.N., Stanfield, R.L., Dyson, H.J., Wright, P.E. (2018) "CH···O Hydrogen Bonds Mediate Highly Specific Recognition of Methylated CpG Sites by the Zinc Finger Protein Kaiso." Biochemistry, 57, 2109-2120. Many eukaryotic transcription factors recognize the epigenetic marker 5-methylcytosine (mC) at CpG sites in DNA. Despite their structural diversity, methyl-CpG-bindingread more Kaiso (zbtb33) zinc finger DNA binding domain in complex with a double cpg-methylated DNA resembling the specific kaiso binding sequence (kbs). 4 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:CcG/cGG, other-contacts, [+]:GcG/cGc, [-]:cGA/TcG, [-]:cGc/GcG
5VMX transcription-DNA X-ray (2.05 Å) Nikolova, E.N., Stanfield, R.L., Dyson, H.J., Wright, P.E. (2018) "CH···O Hydrogen Bonds Mediate Highly Specific Recognition of Methylated CpG Sites by the Zinc Finger Protein Kaiso." Biochemistry, 57, 2109-2120. Many eukaryotic transcription factors recognize the epigenetic marker 5-methylcytosine (mC) at CpG sites in DNA. Despite their structural diversity, methyl-CpG-bindingread more Kaiso (zbtb33) zinc finger DNA binding domain in complex with a hemi cpg-methylated DNA resembling the specific kaiso binding sequence (kbs). 2 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:CcG/CGG, other-contacts, [+]:GcG/CGC
5VMY transcription-DNA X-ray (2.0 Å) Nikolova, E.N., Stanfield, R.L., Dyson, H.J., Wright, P.E. (2018) "CH···O Hydrogen Bonds Mediate Highly Specific Recognition of Methylated CpG Sites by the Zinc Finger Protein Kaiso." Biochemistry, 57, 2109-2120. Many eukaryotic transcription factors recognize the epigenetic marker 5-methylcytosine (mC) at CpG sites in DNA. Despite their structural diversity, methyl-CpG-bindingread more Kaiso (zbtb33) zinc finger DNA binding domain in complex with a hemi cpg-methylated DNA resembling the specific kaiso binding sequence (kbs). 2 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:CcG/CGG, other-contacts, [+]:GcG/CGC
5VMZ transcription-DNA X-ray (2.32 Å) Nikolova, E.N., Stanfield, R.L., Dyson, H.J., Wright, P.E. (2018) "CH···O Hydrogen Bonds Mediate Highly Specific Recognition of Methylated CpG Sites by the Zinc Finger Protein Kaiso." Biochemistry, 57, 2109-2120. Many eukaryotic transcription factors recognize the epigenetic marker 5-methylcytosine (mC) at CpG sites in DNA. Despite their structural diversity, methyl-CpG-bindingread more Kaiso (zbtb33) e535q mutant zinc finger DNA binding domain in complex with a double cpg-methylated DNA resembling the specific kaiso binding sequence (kbs). 4 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:CcG/cGG, other-contacts, [+]:GcG/cGc, [-]:cGA/TcG, [-]:cGc/GcG
6A5N gene regulation-DNA X-ray (2.4 Å) Li, X., Harris, C.J., Zhong, Z., Chen, W., Liu, R., Jia, B., Wang, Z., Li, S., Jacobsen, S.E., Du, J. (2018) "Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation." Proc. Natl. Acad. Sci. U.S.A., 115, E8793-E8802. DNA methylation functions in gene silencing and the maintenance of genome integrity. In plants, non-CG DNA methylation is linked through a self-reinforcing loop withread more Crystal structure of arabidopsis thaliana suvh6 in complex with methylated DNA. 1 5mC group: stacking-with-AA, not-WC-paired, not-in-duplex
6C1A DNA binding protein-DNA X-ray (2.05 Å) Liu, K., Xu, C., Lei, M., Yang, A., Loppnau, P., Hughes, T.R., Min, J. (2018) "Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA." J. Biol. Chem., 293, 7344-7354. Cytosine methylation is a well-characterized epigenetic mark and occurs at both CG and non-CG sites in DNA. Both methylated CG (mCG)- and mCH (H = A, C, or T)-read more Mbd2 in complex with methylated DNA. 2 5mC groups: other-contacts, is-WC-paired, is-in-duplex, [-]:TGT/AcA
6C1T DNA binding protein-DNA X-ray (1.84 Å) Liu, K., Xu, C., Lei, M., Yang, A., Loppnau, P., Hughes, T.R., Min, J. (2018) "Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA." J. Biol. Chem., 293, 7344-7354. Cytosine methylation is a well-characterized epigenetic mark and occurs at both CG and non-CG sites in DNA. Both methylated CG (mCG)- and mCH (H = A, C, or T)-read more Mbd2 in complex with a partially methylated DNA. 1 5mC group: other-contacts, is-WC-paired, is-in-duplex, [+]:AcA/TGT
6C1U DNA binding protein-DNA X-ray (2.3 Å) Liu, K., Xu, C., Lei, M., Yang, A., Loppnau, P., Hughes, T.R., Min, J. (2018) "Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA." J. Biol. Chem., 293, 7344-7354. Cytosine methylation is a well-characterized epigenetic mark and occurs at both CG and non-CG sites in DNA. Both methylated CG (mCG)- and mCH (H = A, C, or T)-read more Mbd2 in complex with a deoxy-oligonucleotide. 2 5mC groups: other-contacts, is-WC-paired, is-in-duplex, [-]:TGT/AcA
6C1Y DNA binding protein-DNA X-ray (2.3 Å) Liu, K., Bian, C., Tempel, W., Wernimont, A.K., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium "mbd of human mecp2 in complex with methylated DNA." to be published   Mbd of human mecp2 in complex with methylated DNA. 4 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:CcG/cGG, [-]:cGG/CcG
6C2F DNA binding protein-DNA X-ray (2.65 Å) Liu, K., Xu, C., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium "MBD2 in complex with methylated DNA." to be published   Mbd2 in complex with methylated DNA. 6 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:CcG/CGG
6CC8 DNA binding protein-DNA X-ray (1.95 Å) Liu, K., Lei, M., Wu, Z., Gan, B., Cheng, H., Li, Y., Min, J. (2019) "Structural analyses reveal that MBD3 is a methylated CG binder." Febs J., 286, 3240-3254. The MBD3, a methyl-CpG-binding domain (MBD)-containing protein, is a core subunit of the Mi-2/NuRD complex. Recent reports show that MBD3 recognizes both methylated CGread more Crystal structure mbd3 mbd domain in complex with methylated cpg DNA. 4 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:AcG/cGT, [-]:cGT/AcG
6CCG transcription X-ray (1.9 Å) Liu, K., Lei, M., Wu, Z., Gan, B., Cheng, H., Li, Y., Min, J. (2019) "Structural analyses reveal that MBD3 is a methylated CG binder." Febs J., 286, 3240-3254. The MBD3, a methyl-CpG-binding domain (MBD)-containing protein, is a core subunit of the Mi-2/NuRD complex. Recent reports show that MBD3 recognizes both methylated CGread more Crystal structure mbd3 mbd domain in complex with methylated cpg DNA. 4 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:GcG/cGC, [-]:cGC/GcG
6CEU transcription-DNA X-ray (2.01 Å) Liu, K., Lei, M., Wu, Z., Gan, B., Cheng, H., Li, Y., Min, J. (2019) "Structural analyses reveal that MBD3 is a methylated CG binder." Febs J., 286, 3240-3254. The MBD3, a methyl-CpG-binding domain (MBD)-containing protein, is a core subunit of the Mi-2/NuRD complex. Recent reports show that MBD3 recognizes both methylated CGread more Mbd3 mbd in complex with methylated, non-palindromic cpg DNA: alternative interpretation of crystallographic data. 4 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:GcG/cGC, [-]:cGT/AcG
6CNP transcription-DNA X-ray (2.1 Å) Liu, K., Xu, C., Lei, M., Yang, A., Loppnau, P., Hughes, T.R., Min, J. (2018) "Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA." J. Biol. Chem., 293, 7344-7354. Cytosine methylation is a well-characterized epigenetic mark and occurs at both CG and non-CG sites in DNA. Both methylated CG (mCG)- and mCH (H = A, C, or T)-read more Crystal structure of mbd2 complex with methylated cpg island. 4 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:CcG/cGG, [-]:cGG/CcG
6CNQ transcription-DNA X-ray (2.15 Å) Liu, K., Xu, C., Lei, M., Yang, A., Loppnau, P., Hughes, T.R., Min, J. (2018) "Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA." J. Biol. Chem., 293, 7344-7354. Cytosine methylation is a well-characterized epigenetic mark and occurs at both CG and non-CG sites in DNA. Both methylated CG (mCG)- and mCH (H = A, C, or T)-read more Mbd2 in complex with methylated DNA. 4 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:AcG/cGT, [-]:cGT/AcG
6D1T DNA binding protein-DNA X-ray (2.25 Å) Liu, K., Xu, C., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium "Complex of MBD1-MBD and methylated DNA." to be published   Complex of mbd1-mbd and methylated DNA. 2 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:AcG/cGT, [-]:cGT/AcG
6E93 DNA binding protein-DNA X-ray (1.75 Å) Hudson, N.O., Whitby, F.G., Buck-Koehntop, B.A. (2018) "Structural insights into methylated DNA recognition by the C-terminal zinc fingers of the DNA reader protein ZBTB38." J. Biol. Chem., 293, 19835-19843. Methyl-CpG-binding proteins (MBPs) are selective readers of DNA methylation that play an essential role in mediating cellular transcription processes in both normalread more Crystal structure of zbtb38 c-terminal zinc fingers 6-9 in complex with methylated DNA. 3 5mC groups: hydrophobic-with-AA, is-WC-paired, is-in-duplex, [+]:GcG/cGC, [+]:CcG/cGG, other-contacts, [-]:cGA/TcG
6E94 DNA binding protein-DNA X-ray (1.59 Å) Hudson, N.O., Whitby, F.G., Buck-Koehntop, B.A. (2018) "Structural insights into methylated DNA recognition by the C-terminal zinc fingers of the DNA reader protein ZBTB38." J. Biol. Chem., 293, 19835-19843. Methyl-CpG-binding proteins (MBPs) are selective readers of DNA methylation that play an essential role in mediating cellular transcription processes in both normalread more Crystal structure of zbtb38 c-terminal zinc fingers 6-9 k1055r in complex with methylated DNA. 3 5mC groups: hydrophobic-with-AA, is-WC-paired, is-in-duplex, [+]:GcG/cGC, stacking-with-AA, [+]:CcG/cGG, other-contacts, [-]:cGA/TcG
6JNM DNA binding protein-DNA X-ray (2.05 Å) Qiu, Q., Mei, H., Deng, X., He, K., Wu, B., Yao, Q., Zhang, J., Lu, F., Ma, J., Cao, X. (2019) "DNA methylation repels targeting of Arabidopsis REF6." Nat Commun, 10, 2063-2063. RELATIVE OF EARLY FLOWERING 6 (REF6/JMJ12), a Jumonji C (JmjC)-domain-containing H3K27me3 histone demethylase, finds its target loci in Arabidopsis genome by directlyread more Ref6 znf2-4-nac004-mc3 complex. 2 5mC groups: other-contacts, is-WC-paired, is-in-duplex, [+]:TcT/AGA, [-]:AGA/TcT
6JNN DNA binding protein-DNA X-ray (2.6 Å) Qiu, Q., Mei, H., Deng, X., He, K., Wu, B., Yao, Q., Zhang, J., Lu, F., Ma, J., Cao, X. (2019) "DNA methylation repels targeting of Arabidopsis REF6." Nat Commun, 10, 2063-2063. RELATIVE OF EARLY FLOWERING 6 (REF6/JMJ12), a Jumonji C (JmjC)-domain-containing H3K27me3 histone demethylase, finds its target loci in Arabidopsis genome by directlyread more Ref6 znf2-4-nac004-mc1 complex. 4 5mC groups: other-contacts, is-WC-paired, is-in-duplex, [-]:AGA/TcT, [+]:TcT/AGA
6MG2 transcription-DNA X-ray (1.93 Å) Yang, J., Horton, J.R., Wang, D., Ren, R., Li, J., Sun, D., Huang, Y., Zhang, X., Blumenthal, R.M., Cheng, X. (2019) "Structural basis for effects of CpA modifications on C/EBP beta binding of DNA." Nucleic Acids Res., 47, 1774-1785. CCAAT/enhancer binding proteins (C/EBPs) regulate gene expression in a variety of cells/tissues/organs, during a range of developmental stages, under bothread more C-terminal bzip domain of human c-ebpbeta with 16bp methylated oligonucleotide containing consensus recognition sequence-c2221 crystal form. 4 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:GcG/cGc, hydrophobic-with-AA, [+]:GcA/TGc, other-contacts, [-]:cGc/GcG, [-]:TGc/GcA
6MG3 transcription-DNA X-ray (2.05 Å) Yang, J., Horton, J.R., Wang, D., Ren, R., Li, J., Sun, D., Huang, Y., Zhang, X., Blumenthal, R.M., Cheng, X. (2019) "Structural basis for effects of CpA modifications on C/EBP beta binding of DNA." Nucleic Acids Res., 47, 1774-1785. CCAAT/enhancer binding proteins (C/EBPs) regulate gene expression in a variety of cells/tissues/organs, during a range of developmental stages, under bothread more V285a mutant of the c-terminal bzip domain of human c-ebpbeta with 16bp methylated oligonucleotide containing consensus recognition sequence. 4 5mC groups: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:GcG/cGc, hydrophobic-with-AA, [+]:GcA/TGc, other-contacts, [-]:cGc/GcG, [-]:TGc/GcA
6ML6 transcription-DNA X-ray (1.54 Å) Ren, R., Hardikar, S., Horton, J.R., Lu, Y., Zeng, Y., Singh, A.K., Lin, K., Coletta, L.D., Shen, J., Shuet, C., Kong, L., Hashimoto, H., Zhang, X., Chen, T., Cheng, X. (2019) "Structural basis of specific DNA binding by the transcription factor ZBTB24." Nucleic Acids Res. ZBTB24, encoding a protein of the ZBTB family of transcriptional regulators, is one of four known genes-the other three being DNMT3B, CDCA7 and HELLS-that are mutatedread more Zbtb24 zinc fingers 4-8 with 19+1mer DNA oligonucleotide (sequence 4 with a cpa 5mc modification). 1 5mC group: stacking-with-AA, is-WC-paired, is-in-duplex, [+]:GcA/TGC
6ML7 transcription-DNA X-ray (1.75 Å) Ren, R., Hardikar, S., Horton, J.R., Lu, Y., Zeng, Y., Singh, A.K., Lin, K., Coletta, L.D., Shen, J., Shuet, C., Kong, L., Hashimoto, H., Zhang, X., Chen, T., Cheng, X. (2019) "Structural basis of specific DNA binding by the transcription factor ZBTB24." Nucleic Acids Res. ZBTB24, encoding a protein of the ZBTB family of transcriptional regulators, is one of four known genes-the other three being DNMT3B, CDCA7 and HELLS-that are mutatedread more Zbtb24 zinc fingers 4-8 with 19+1mer DNA oligonucleotide (sequence 4 with a cpg 5mc modification). 1 5mC group: other-contacts, is-WC-paired, is-in-duplex, [+]:AcG/CGT
6OGK DNA binding protein-DNA X-ray (1.65 Å) Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J. "MeCP2 MBD in complex with DNA." To Be Published   Mecp2 mbd in complex with DNA. 1 5mC group: other-contacts, is-WC-paired, is-in-duplex, [+]:AcA/TGT
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